IChMASCOT is flexible and user friendly software for the global kinetic modeling
of ion channel gating.
This program optimizes the rate constants for a given kinetic model using the
macroscopic experimental data.
Features:
Experimental data:
- Ionic currents.
- Gating currents.
- Steady state properties.
- Time constants.
Global fit:
- Multiple experiments.
- Independent experimental conditions.
- Voltage.
- Ion concentrations.
- Temperature.
- Complex protocols.
Control in the global fit:
- Selection of the free and fix parameters.
- Selection of parameters boundaries.
- Weight factors.
- Independent conductance for each experiment.
Kinetic Models:
- Single kinetic model.
- Independent gates model.
- 3D models.
- Predefined rate constant or arbitrary functions.
- Voltage and/or ligand dependent rate constants.
- Ohmic, GHK or arbitrary conductance.
IChMASCOT includes several tools of the program IChSimLab such as: ion channel
math library, model editor and protocol editor. These tools allow user-friendly
edition of global fit projects.