IChMASCOT is flexible and user friendly software for the global kinetic modeling of ion channel gating.
This program optimizes the rate constants for a given kinetic model using the macroscopic experimental data. 

Features:

Experimental data:

• Ionic currents.
• Gating currents.
• Steady state properties.
• Time constants.
   

Global fit:

• Multiple experiments.
• Independent experimental conditions.
• Voltage.
• Ion concentrations.
• Temperature.
• Complex protocols.

Control in the global fit:

• Selection of the free and fix parameters.
• Selection of parameters boundaries.
• Weight factors.
• Independent conductance for each experiment.

Kinetic Models:

• Single kinetic model.
• Independent gates model.
• 3D models.
• Predefined rate constant or arbitrary functions.
• Voltage and/or ligand dependent rate constants.
• Ohmic, GHK or arbitrary conductance.

 IChMASCOT includes several tools of the program IChSimLab such as: ion channel math library, model editor and protocol editor. These tools allow user-friendly edition of global fit projects.